In a bid to enhance our understanding of ageing, a team of scientists has uncovered the intricate mechanisms by which immunoglobulins influence the ageing process.By analysing millions of spatial spots across nine organs in male mice, the team from the Chinese Academy of Sciences (CAS) and BGI Research created high-precision spatial transcriptomic maps.
These maps detailed the spatial distribution of over 70 cell types, offering a vivid picture of agingās spatial characteristics.
The transcriptomic landscape, dubbed Gerontological Geography (GG), exposes the common threads of tissue structural disorder and loss of cellular identity as hallmarks of aging.
āThis landscape is a significant step forward, pinpointing the epicenters of ageing within multiple organs and uncovering the accumulation of immunoglobulins as a key aging characteristic and driver,ā said Professor Liu Guanghui, one of the corresponding authors of the study published in the journal Cell.