The recent surge in popularity of weight loss drugs like Ozempic, collectively called GLP-1s, has sparked renewed scientific interest in understanding how our bodies regulate muscle growth. In a recent study, scientists have linked the protein BCL6 to the maintenance of muscle mass and further suggested that BCL6-boosting therapeutics could help GLP-1 users retain muscle while losing fat.Similar therapies could also be used to treat other populations prone to muscle loss, such as older adults and patients with systemic diseases like sepsis or cancer.
A new study from the Salk Institute has revealed that a protein called BCL6 is key to maintaining healthy muscle mass. The experiments showed that mice with lower levels of BCL6 had significantly reduced muscle mass and strength, but increasing BCL6 successfully reversed those losses.
The results suggest that pairing GLP-1 medications with a BCL6-boosting drug may help counteract unwanted muscle loss. Similar therapies could also be used to treat other populations prone to muscle loss, such as older adults and patients with systemic diseases like sepsis or cancer.
The findings were published in the Proceedings of the National Academy of Sciences on January 22, 2025.
“Muscle is the most abundant tissue in the human body, so its maintenance is critical to our health and quality of life,” says Ronald Evans, professor and director of the Gene Expression Laboratory at Salk.
“Our study reveals how our bodies coordinate the upkeep of all this muscle with our nutrition and energy levels, and with this new insight, we can develop therapeutic interventions for patients losing muscle as a side effect of weight loss, age, or illness.” Ronald added.